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目的:探讨语前聋患儿耳蜗不同刺激部位的电诱发听神经复合动作电位(ECAP)之间是否存在差异。方法:应用NRT软件分别对32例Nucleus CI24R(CA)语前聋儿童植入者的第1、4、7、11、17、22号电极进行术中监测,对幅值增长函数进行线性拟合以确定ECAP幅值、阈值及幅值增长曲线斜率,按照耳蜗顶部、中部、底部不同刺激部位分析其差异,并且探讨不同刺激部位之间ECAP不应期的特点。结果:ECAP阈值自蜗底至蜗顶呈下降趋势,反应幅值自蜗底至蜗顶呈上升趋势,幅值增长曲线斜率自蜗底至蜗顶呈上升趋势,不应期恢复曲线幅值自蜗底至蜗顶呈上升趋势,耳蜗位置不同对不应期有整体影响,但不同部位之间两两相比无明显差异。结论:对于语前聋患儿,刺激耳蜗不同部位ECAP阈值、幅值及幅值增长曲线斜率、不应期恢复曲线幅值显著不同,对不应期有整体影响,但各部位间无系统差异。
Objective: To investigate whether there is a difference between the electrical evoked auditory nerve complex action potentials (ECAP) at different stimulation sites of cochlear in children with prelingual deafness. METHODS: NRT software was used to monitor the electrodes of Nos. 1, 4, 7, 11, 17 and 22 of 32 children with Nucleus CI24R (CA) prelingual deafness respectively. The amplitude growth function was linearly fitted To determine the slope of ECAP amplitude, threshold and amplitude growth curve, the differences of cochlear top, middle and bottom stimuli were analyzed, and the ECAP refractory period between different stimuli was discussed. Results: The ECAP threshold decreased from the bottom to the top of the cochlea. The amplitude of the response curve increased from the bottom of the cochlear to the top of the cochlea. The slope of the amplitude increasing curve increased from the bottom to the top of the cochlea. Cochlear to cochlear upward trend, cochlear different positions on the refractory period of the overall impact, but no significant difference between the two parts of different parts. CONCLUSIONS: For children with prelingual deafness, the slope of ECAP threshold, amplitude and amplitude growth curve in different parts of cochlea stimulated significantly different amplitude of recovery curve of refractory period, but had no effect on refractory period but there was no systematic difference .