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用兔抗人α-心房利钠多肽(atrial natriure-tic peptide,ANP)血清和PAP免疫组织化学方法,观察到恒河猴脾白髓和肾髓质上皮细胞中存在ANP样免疫活性物质,其棕色颗粒,主要分布于细胞核周质内。猴脾提取物经Seph-adex G-15分离,可得到具有降压、利尿、利钠的组分,这些活性多肽的结构和功能需待进一步研究。
ANP-like immunoreactive substances were observed in the rhesus monkey splenocytes and renal medulla epithelium using rabbit anti-human atrial natriuretic peptide (ANP) sera and PAP immunohistochemistry Brown particles, mainly distributed in the nucleus periplasm. The extract of monkey spleen is separated by Seph-adex G-15 to obtain the components with antihypertensive, diuretic and natriuretic effects. The structure and function of these active peptides need further study.