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中国药典中规定葡葡糖酸钙注射剂得添加 d-糖酸钙或其他适宜的钙盐为稳定剂。并规定加入钙盐的量,依钙计算,不得超过葡萄糖酸钙含有的钙量的5%。这说明中国药典对葡萄糖钙的要求相当严格。药典中未规定可以加任何酸类作稳定剂,当然不可用盐酸作本注射剂的稳定剂。因原收上任何助溶剂对主要药物只应起物理作用,不应影响疗效、更不应影响主要药物的结构。葡萄糖酸是一种弱的有机酸,所成的钙盐遇强酸尤其是盐酸,即分解成氯化钙和游离葡萄糖酸。
Chinese Pharmacopoeia provides calcium gluconate injection to add calcium d-gluconate or other suitable calcium salt as a stabilizer. And the provisions of the amount of calcium salt, calculated according to calcium, calcium gluconate may not exceed 5% of the calcium content. This shows that the Chinese Pharmacopoeia on calcium glucose requirements are quite strict. Pharmacopoeia is not provided for any acid can be added as a stabilizer, of course, can not be used as hydrochloric acid hydrochloride injection stabilizer. Because the original received any cosolvent on the main drug should only play a physical role, should not affect the efficacy, but should not affect the structure of the main drug. Gluconic acid is a weak organic acid, the resulting calcium salt met strong acid, especially hydrochloric acid, that is, decomposed into calcium chloride and free gluconic acid.