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关于男性不育患者中染色体异常的频率已有报道。一些较大的异常(如Klinefelter综合征,性染色体的各种数目异常,常染色体结构重排以及罗伯逊易位)被认为与不育有关,但一些微小的异常(随体变大与加倍,近端着丝粒染色体短臂的扩大,副缢痕的变长)却被认为没有临床意义。由于原位杂交法将DNA 定位在D、G 组染色体的短臂尤其是随体柄上,使这一局部区域显得重要。本研究的目的在于评价能育与不育男性的近端着丝粒染色体微小异常的频率。
The frequency of chromosomal abnormalities in male infertility has been reported. Some of the larger anomalies (such as Klinefelter syndrome, various numbers of sex chromosome abnormalities, autosomal rearrangements, and Robertsonian translocations) are thought to be associated with infertility, but some minor abnormalities (larger and larger as the body approaches, An increase in the short arm of the telocentric chromosome, variable length of secondary stapes) is considered of no clinical significance. Since the in situ hybridization DNA is located in the D, G chromosomes on the short arm, especially with the stalk, make this part of the region is important. The purpose of this study was to evaluate the frequency of subacute centromere chromosomal abnormalities in fertile and infertile men.