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目的:探讨高频振荡叠加常频通气联合西地那非治疗新生儿持续肺动脉高压的疗效。方法:选取2012年1月~2013年12月住院诊断为持续肺动脉高压的新生儿65例,按治疗条件分为高频振荡通气(HFOV)联合西地那非组、常频机械通气(CMV)联合西地那非组、高频振荡叠加常频通气联合西地那非组及西地那非组,比较各组患儿治疗前及治疗后6、12、24、36 h的氧合指数(OI)及血氧饱和度(SPO2)。结果:各组治疗前各项血气指标比较差异无统计学意义(P>0.05),治疗后OI、动脉/肺泡氧分压分数(a/APO2)均随着治疗时间的延长而逐渐改善,SPO2逐渐增高,高频振荡叠加常频通气联合西地那非组较其他各组改善更明显(P<0.05),治疗有效率更高(P<0.05)。结论:高频振荡叠加常频通气联合西地那非治疗新生儿持续肺动脉高压的疗效确切,对于改善肺通气,降低肺动脉压效果良好,值得临床推广。
Objective: To investigate the effect of high-frequency oscillatory superimposition and frequent ventilatory ventilation in combination with sildenafil on neonatal persistent pulmonary hypertension. Methods: A total of 65 newborns diagnosed as persistent pulmonary hypertension in our hospital from January 2012 to December 2013 were divided into high frequency oscillatory ventilation (HFOV) group and sildenafil group according to the treatment conditions, and the frequency of mechanical ventilation (CMV) Combined with sildenafil group, high-frequency oscillatory superimposed frequency-added ventilation and sildenafil group and sildenafil group, compared before and after treatment, 6,12,24,36 h oxygenation index ( OI) and oxygen saturation (SPO2). Results: There was no significant difference in each index of blood gas between before and after treatment (P> 0.05). After treatment, the OI and a / APO2 of aorta / alveolar were gradually improved with the prolongation of treatment time. SPO2 (P <0.05). The treatment efficiency was higher (P <0.05). CONCLUSION: The combination of high-frequency oscillatory superimposition and frequent ventilatory ventilation combined with sildenafil in the treatment of neonatal persistent pulmonary hypertension has definite curative effect. It is worthy of clinical promotion to improve pulmonary ventilation and reduce pulmonary arterial pressure.