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目的 :探讨冠心病 (CHD)患者血浆肿瘤坏死因子 α(TNF α)和可溶性肿瘤坏死因子受体 (STNFR)与冠状动脉狭窄病变的关系。方法 :12 0例拟诊CHD的住院患者 ,根据冠状动脉造影 (CAG)结果分成正常对照组 ( 2 7例 ) ,冠状动脉轻度狭窄组 ( 2 8例 ) ,中度狭窄组 ( 3 5例 ) ,重度狭窄组 ( 3 0例 )。所有患者均在CAG当日清晨采取肘静脉血 ,采用酶联免疫双抗体夹心法测定TNF α和STNFR。结果 :CHD组与对照组比较 ,TNF α和STNFR水平均明显高于对照组 (P <0 .0 1)。在CHD的亚组中 ,冠状动脉轻度狭窄组高于对照组 (P <0 .0 5 ) ,中、重度狭窄组与轻度狭窄组比较均明显增高(P <0 .0 1)。CHD组TNF α与STNFR水平呈显著性正相关关系 (r =0 .68,P <0 .0 1)。结论 :提示TNF α和STNFR参与CHD的发生发展过程 ,冠心病患者血浆TNF α和STNFR水平与冠状动脉狭窄病变的程度有关 ,血浆TNF α和STNFR水平及其比值可能对反映冠状动脉硬化病变的严重程度有重要价值。
Objective: To investigate the relationship between plasma tumor necrosis factor α (TNF α) and soluble tumor necrosis factor receptor (STNFR) and coronary artery stenosis in patients with coronary heart disease (CHD). Methods: A total of 120 hospitalized patients with CHD were divided into control group (27 cases), mild coronary stenosis group (28 cases) and moderate stenosis group (35 cases) according to coronary angiography (CAG) ), Severe stenosis group (30 cases). All patients took elbow venous blood in the early morning of CAG, TNFα and STNFR were determined by enzyme-linked immunosorbent assay (ELISA). Results: The levels of TNFα and STNFR in CHD group were significantly higher than those in control group (P <0.01). In the CHD subgroup, mild coronary stenosis group was higher than that of the control group (P <0.05), moderate and severe stenosis group was significantly higher than the mild stenosis group (P <0.01). There was a significant positive correlation between TNFα and STNFR in CHD group (r = 0.68, P <0.01). CONCLUSIONS: TNFα and STNFR are involved in the pathogenesis of CHD. The levels of plasma TNFαand STNFR in patients with coronary heart disease are related to the severity of coronary artery stenosis. The levels of plasma TNFαand STNFR and their ratios may reflect the severity of coronary atherosclerosis Degree has important value.