论文部分内容阅读
目的采用不同类型的炎症动物模型评价一枝蒿(AR)提取物的抗炎作用。方法采用二甲苯致小鼠耳肿胀实验,角叉菜胶致大鼠足跖肿胀实验、小鼠气囊肿实验、棉球肉芽肿实验等。结果一枝蒿提取物对急性、慢性炎症及炎性渗出均有明显的抑制作用,抑制炎症介质PGE2的产生,并抑制白细胞游走。结论AR提取物具有明显抗炎作用,其作用与抑制炎症介质PGE2产生有关。
Objective To evaluate the anti-inflammatory effects of Artemisia halodendron (AR) extracts using different types of inflammatory animal models. Methods Xylene-induced mouse ear swelling test, carrageenan-induced rat paw edema test, mouse airbag experiment, cotton ball granuloma experiment were used. Results The extract of Artemisia halodendron had significant inhibitory effect on acute and chronic inflammation and inflammatory exudation, inhibited the production of PGE2, and inhibited leukocyte migration. Conclusion The AR extract has obvious anti-inflammatory effects, and its action is related to the inhibition of PGE2 production in inflammatory mediators.