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蛋白磷酸酶1靶调节亚基（ PNUTS）是主要位于细胞核内广泛表达的蛋白质，其编码基因位于染色体6P21.3，容易突变。既往的研究发现，在哺乳动物细胞中 PNUTS 作为蛋白磷酸酶1（ PP1）靶调节亚基，与PP1稳定的结合，并调节其催化活性，在细胞有丝分裂不同时期与染色质共定位，通过调控多种靶分子参与细胞的增殖与凋亡。有关 PNUTS的研究现已迅速成为生命科学领域研究的热点。近年来研究发现PNUTS在细胞凋亡、肿瘤形成、衰老、心血管疾病发生发展等方面起着重要的作用。“,”Phosphatase 1 nuclear-targeting subunit ( PNUTS) is a ubiquitously expressed protein and its coding gene is on chromosome 6P21.3,with easy mutation.Previous studies have found that PNUTS functions as a nuclear regulatory subunit of PP1,forms a stable complex with PP1 and regulates PP1 catalytic activity in mammalian cells.PNUTS os colocalized with chromatin at distinct phases during mitosis ,involved in cell pro-liferation and apoptosis by regulating various target molecules .Research related to PNUTS is now a hotspot in the field of life science.Recent studies have found that PNUTS plays an important role in the development of apoptosis,tumorigenesis,senescence,cardiovascular diseases and other physiological contexts.