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目的探讨结核感染T细胞斑点试验(T-SPOT.TB)诊断乳腺结核的临床价值。方法 13例经组织病理学检查证实的单纯乳腺结核患者(乳腺结核组),10例体检健康者为对照组,均行T-SPOT.TB和结核菌素皮肤试验(tuberculin skin test,TST)检测。与组织病理学检查结果进行对照,比较2种方法诊断乳腺结核的敏感性和特异性。结果乳腺结核组T-SPOT.TB检测11例阳性、2例阴性,TST检测7例阳性、6例阴性;对照组T-SPOT.TB检测2例阳性、8例阴性,TST检测4例阳性、6例阴性;T-SPOT.TB诊断乳腺结核的敏感性(84.6%)高于TST(53.8%)(P<0.05),特异性(80.0%)与TST(60.0%)比较差异无统计学意义(P>0.05)。结论 T-SPOT.TB是诊断乳腺结核的敏感性较高的辅助方法,对乳腺结核的早期诊断有重要价值。
Objective To investigate the clinical value of T-SPOT.TB in the diagnosis of breast tuberculosis. Methods T-SPOT.TB and tuberculin skin test (TST) were used in 13 cases of simple tuberculosis (tuberculosis) and 10 cases of healthy controls (confirmed by histopathology) . And histopathological examination results were compared, two methods to compare the sensitivity and specificity of diagnosis of breast tuberculosis. Results T-SPOT.TB in breast tuberculosis group was positive in 11 cases and negative in 2 cases. TST was positive in 7 cases and negative in 6 cases. T-SPOT.TB in control group was positive in 2 cases, negative in 8 cases, positive in 4 cases by TST, 6 cases were negative. The sensitivity of T-SPOT.TB in diagnosis of tuberculosis was higher than that of TST (53.8%) (P <0.05), and specificity (80.0%) was not significantly different from that of TST (P> 0.05). Conclusion T-SPOT.TB is a sensitive method to diagnose breast tuberculosis, which is of great value in the early diagnosis of breast tuberculosis.