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阻塞性睡眠呼吸暂停综合征(OSAS)可导致身体多器官系统的损害。目前的研究证实OSAS是致高血压发生的重要独立危险因素,并被列为继发性高血压的首位致病因素[1]。动物实验发现,夜间反复发生的阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)事件在1～3个月内可使受试动物的血压无论在清醒或睡眠状态下均升高;当消除OSA事件后血压在1～4周内又回落至正常水平。若在夜间给予狗声觉刺激并保持其上气道通畅,虽无OSA事件发生,狗的微觉醒次数及血压急性升高程度仍与OSA事件存在时的情况一致,然而日间血压却不升高[2]。
Obstructive sleep apnea syndrome (OSAS) can lead to multiple organ system damage. The current study confirms that OSAS is an important independent risk factor for hypertension and is listed as the first causative agent of secondary hypertension [1]. Animal experiments found that night repeated episodes of obstructive sleep apnea (obstructive sleep apnea, OSA) in 1 to 3 months to make the test animals blood pressure regardless of awake or sleep are elevated; when the elimination of OSA events After the blood pressure in 1 to 4 weeks and returned to normal levels. If the dog was given nociceptive stimulation at night and kept its upper airway unobstructed, no OSA occurred, the number of dog arousals and the acute rise in blood pressure were still consistent with those at the time of OSA, whereas daytime blood pressure did not rise High [2].