目的探讨腹腔镜下病灶切除术联合孕三烯酮治疗子宫腺肌瘤的疗效。方法将64例痛经、月经不规则、B超确诊为子宫腺肌瘤、有保留子宫需求的患者随机分为两组,治疗组34例在腹腔镜下行子宫肌瘤切除术,术后给予孕三烯酮2.5mg口服;对照组30例仅给予病灶切除术,比较两组临床疗效,随访6个月,观察痛经缓解和月经改善情况。结果治疗组手术时间、术后出血量、术后肛门排气时间均明显低于对照组(P<0.05);术后6个月,治疗组痛经缓解率、月经改善率均明显高于对照组(P<0.05),治疗组复发率明显低于对照组(P<0.05)。结论腹腔镜下病灶切除术联合孕三烯酮治疗子宫腺肌瘤疗效显著,改善临床症状,降低复发率,保留生育功能。 Objective To investigate the efficacy of laparoscopic resection combined with gestrinone in the treatment of adenomyosis. Methods 64 cases of dysmenorrhea, irregular menstruation and B-ultrasound were diagnosed as adenomyoma, and patients with reserved uterus were randomly divided into two groups. 34 cases in the treatment group underwent laparoscopic myomectomy, Enketene 2.5mg orally; control group, 30 cases were given focal resection, the clinical efficacy of two groups were compared, followed up for 6 months to observe the relief of dysmenorrhea and menstrual improvement. Results The operation time, postoperative blood loss and postoperative anal exhaust time in the treatment group were significantly lower than those in the control group (P <0.05). At 6 months after operation, the rates of relief of dysmenorrhea and improvement of menstruation in the treatment group were significantly higher than those in the control group (P <0.05), and the recurrence rate of the treatment group was significantly lower than that of the control group (P <0.05). Conclusion laparoscopic resection combined with gestrinone treatment of adenomyosis significant effect, improve clinical symptoms, reduce the recurrence rate, retain reproductive function.