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本文报告抗高血压药碘杂环—64(IHC—64)对小鼠免疫功能的影响,并同免疫抑制剂CY和强的松龙进行比较。IHC—64 1.5,3mg/kg ip×7对小鼠胸腺重、牌重无显著影响,但对PHA6mg/kgim×3诱导的体内淋巴细胞转化有明显促进作用。相同剂量给药4天,IHC—64不但对SRBC所致的血清溶血素、凝集素的产生无明显影响而且对小鼠脾脏抗体形成细胞(PFC)特异性玫瑰花形成细胞(SRFC)和脾细胞总数均无显著影响。说明IHC—64对免疫功能有选择性促进作用。
This article reported the effect of the antihypertensive drug Iodocyste-64 (IHC-64) on immune function in mice and compared it with immunosuppressant CY and prednisolone. IHC-64 1.5,3mg/kg ip×7 had no significant effect on the thymus weight or the weight of the mice, but it could significantly promote the lymphocyte transformation induced by PHA6mg/kgim×3 in vivo. At the same dose for 4 days, IHC-64 not only had no significant effect on the production of serum hemolysin and lectin caused by SRBC, but also had specific rose formation cells (SRFC) and spleen cells on mouse spleen antibody-forming cells (PFC). The total number has no significant effect. This shows that IHC-64 has selective promotion of immune function.