肌注免疫球蛋白可致无丙种球蛋白血症患者细菌感染率明显降低,但有注射部位疼痛、IgG吸收缓慢及局部蛋白水解。静注免疫球蛋白(IVIG)无肌注所致的局部疼痛,治疗剂量亦大得多,并且可使血清抗体浓度迅速升高。目前美国食品及药物管理局已批准6种IVIG制剂用于治疗。 IVIG的制备几乎所有IVIG制剂均系通过Cohn酒精分馏法或其改良法从正常血浆中分离而得 Intramuscular immunoglobulin can cause no gammoblastosis in patients with bacterial infection was significantly lower, but there is injection site pain, IgG absorption and local proteolysis. Intravenous immunoglobulin (IVIG) without local pain caused by intramuscular injection, the treatment dose is also much larger, and serum antibody concentrations can be rapidly increased. Currently, six FDA-approved IVIGs have been approved by the U.S. Food and Drug Administration for treatment. Preparation of IVIG Almost all IVIG preparations were isolated from normal plasma by Cohn alcohol fractionation or its modification