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目的:探讨宫颈癌前病变中检测高危型HPV病毒负荷的意义。方法:将2011年1月～2012年6月就诊的268例患者根据阴道镜下子宫颈病理结果分为正常组、CINⅠ组、CINⅡ组、CINⅢ组。采用美国Digene公司第二代基因杂交捕获信号放大检测试验,检测所有患者的HPV病毒含量,比较各组HR-HPV DNA阳性率及其在中度、低度、高度的分布比例,分析宫颈癌前病变与HPV病毒量的关系。结果:正常组、CIN-I组、CIN-II组、CIN-III组的HPV DNA阳性率分别为32.16%、53.19%、78.57%、87.5%;正常组在低度的分布比例显著低于CIN各组,而CIN各组在中高度的分布比例显著高于正常组,且差异均具统计学意义(P<0.05)。结论:高危型HPV负荷量与宫颈癌前病变的发生发展有明显的相关性,具有较高的筛查和诊治意义。
Objective: To investigate the significance of detection of high-risk HPV infection in cervical precancerous lesions. Methods: According to the result of colposcopy, 268 patients treated from January 2011 to June 2012 were divided into normal group, CINⅠgroup, CINⅡgroup and CINⅢgroup. Using the second-generation gene hybridization capture signal amplification test of Digene in the United States, all patients were tested for HPV virus content, HR-HPV DNA positive rate of each group and its distribution in moderate, low, high, The Relationship Between Lesions and HPV Viruses. Results: The positive rates of HPV DNA in normal group, CIN-I group, CIN-II group and CIN-III group were 32.16%, 53.19%, 78.57% and 87.5% respectively. The distribution of HPV DNA in normal group was significantly lower than that in CIN The distribution of CIN in each group was significantly higher than that in the normal group, and the difference was statistically significant (P <0.05). Conclusion: The load of high-risk HPV has a clear correlation with the occurrence and development of precancerous lesions of cervix, which has high significance in screening and diagnosis.