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以往本实验室研究表明对实验动物应用Vit E可防止其急性CCl_4性肝坏死,本文研究给大鼠饮食补充Vit E后是否影响CCl_4引起的慢性肝损害和肝硬化。材料和方法:将最初体重为40～50 g的雄性幼年Wistar大鼠分两组饲养,Ⅰ组用标准饲料(含Vit E50mg/kg),Ⅱ组在标准饲料中加用Vit E(Vit E总量250mg/kg)。饲养3周后分别从两组中选体重为130～140g大鼠的腹腔内注射CCl_4 0.15ml,每周3次,计5周以上。Ⅰ组为对照组(n=10),Ⅱ组为饮食补充Vit E组(n=10),Ⅲ组为标准饲料加CCl_4组(n=12),Ⅳ组为
Previous laboratory studies have shown that the application of Vit E in experimental animals can prevent its acute CCl4-induced hepatic necrosis. In this paper, we investigated whether dietary Vit E supplementation could affect CCl_4-induced chronic liver injury and cirrhosis. MATERIALS AND METHODS: Male Wistar rats aged 40-50 g were bred in two groups. Group I was fed standard diet (Vit E 50 mg / kg), Group II was fed Vit E Amount 250 mg / kg). Three weeks after feeding, two groups of 130-140g weight-bearing rats were injected intraperitoneally with 0.15 ml of CCl 4, 3 times a week for more than 5 weeks. The rats in group Ⅰ were fed with vitamin E (n = 10), group Ⅲ with standard diet plus CCl_4 (n = 12), and in group Ⅳ as