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目的对３３例常年性变应性鼻炎患者进行针刺治疗，以观察其对血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）及鼻粘膜微血管的影响。方法①血浆ＥＴ测定：采用特异性放射免疫法（均相竞争法）直接测定血浆ＥＴ含量。②鼻粘膜微血管的观察：主要观察鼻粘膜微血管管径、管袢数及鼻粘膜微血管的形态。③针刺治疗：选择曲池、血海两穴进行针刺。结果变应性鼻炎患者鼻粘膜微血管管径针刺后较针刺前增粗；针刺后变应性鼻炎患者鼻粘膜微血管形态变化以灯丝状微血管增多、网络状微血管减少为特征；变应性鼻炎患者鼻粘膜微血管管袢数针刺后较针刺前增多；变应性鼻炎患者针刺后血浆ＥＴ含量明显降低。结论变应性鼻炎针刺后鼻粘膜微循环明显改善，表现为鼻粘膜微血管管径增粗，灯丝状微血管增多、网络状微血管减少，管拌数增加，并与血浆ＥＴ存在密切关系，其机理可能是通过降低血浆ＥＴ的水平而起作用的。
Objective To observe the effects of acupuncture on endothelin (ET) and nasal mucosa in 33 patients with perennial allergic rhinitis. Methods ① Plasma ET assay: The content of plasma ET was measured directly by specific radioimmunoassay (homogeneous competition method). ② observation of nasal mucosa capillaries: the main observation of nasal mucosa microvessel diameter, the number of tube and nasal mucosa microvascular morphology. ③ acupuncture treatment: Select Qu pool, blood and sea acupuncture points. Results Nasal mucosa microvessel diameter of patients with allergic rhinitis was thicker than that of acupuncture before acupuncture. The morphological changes of nasal mucosa in patients with allergic rhinitis after acupuncture were characterized by filamentous microvascular enlargement and network-like microvascular decrease. Allergic Nasal mucosa in patients with rhinitis after the number of micro-acupuncture increased more than before acupuncture; patients with allergic rhinitis after acupuncture plasma ET levels were significantly lower. Conclusions Nasal mucosal microcirculation after acupuncture is significantly improved in patients with allergic rhinitis, which is characterized by thickening of nasal mucosa capillaries, increasing of filamentous capillaries, reducing of network capillaries and increasing of tube mixing number, and is closely related to plasma ET, and its mechanism May play a role by lowering plasma ET levels.