炎症性肠病(IBD)的病因和发病机制至今仍未完全明确。近年研究认为其发病与免疫、遗传、环境、微生物等因素均有着密切的联系。本文对近年IBD发病机制研究的新进展,包括IBD的易感基因、环境因素对IBD的影响、宿主防御反应与肠道菌群的相互作用以及IBD的肠黏膜屏障和内环境、先天性免疫和获得性免疫情况作一综述。 The etiology and pathogenesis of inflammatory bowel disease (IBD) is still not fully understood. In recent years, research shows that the incidence and immunity, genetic, environmental, microbial and other factors are closely linked. In this paper, recent advances in the pathogenesis of IBD, including IBD susceptibility genes, the impact of environmental factors on IBD, the host defense response and intestinal microflora interactions and IBD’s intestinal mucosal barrier and internal environment, innate immunity and Acquired immunity is reviewed.