论文部分内容阅读
目的探讨三苯氧胺对多药耐药大肠癌患者外周血淋巴细胞膜P-糖蛋白含量的影响及对FOLFOX4方案化疗效果的影响。方法选择淋巴细胞膜P-gp表达阳性大肠癌患者62例,随机分为三苯氧胺组(33例)和单纯化疗组(29例)。应用流式细胞免疫学方法对两组患者治疗前后淋巴细胞膜P-gp含量进行定量研究,观察化疗效果。结果三苯氧胺能显著降低外周血淋巴细胞膜P-gp含量(P<0.01),提高P-gp转阴率(P<0.01),显著提高化疗总有效率(P<0.01)、中位生存期(P<0.05)和1年生存率(P<0.01)。结论三苯氧胺能有效逆转晚期大肠癌多药耐药,提高化疗效果。
Objective To investigate the effect of tamoxifen on the content of P-glycoprotein in peripheral blood lymphocytes of patients with multidrug-resistant colorectal cancer and its effect on the chemotherapy efficacy of FOLFOX4 regimen. Methods Sixty-two patients with positive P-gp positive lymphoma were selected and randomly divided into three groups: tamoxifen (n = 33) and chemotherapy alone (n = 29). Flow cytometry was used to quantitatively study the content of P-gp in lymphocyte membrane of two groups before and after treatment, and the effect of chemotherapy was observed. Results Tamoxifen could significantly reduce the P-gp content in peripheral blood lymphocytes (P <0.01), increase the negative conversion rate of P-gp (P <0.01), significantly increase the overall effective rate of chemotherapy (P <0.01) <0.05) and 1-year survival rate (P <0.01). Conclusion Tamoxifen can effectively reverse the multidrug resistance of advanced colorectal cancer and improve the effect of chemotherapy.