目的 :观察静脉滴注泮托拉唑治疗急性上消化道出血的疗效。方法 :将 70例病人分为 2组 :泮托拉唑治疗组 4 0例 ,静脉滴注泮托拉唑 4 0mg ,q 12h ,持续 2～ 3d ,出血停止后均予泮托拉唑胶囊4 0mg ,po ,qd维持。雷尼替丁对照组 30例 ,静脉滴注雷尼替丁 15 0～ 2 0 0mg ,q 12h ,持续 2～ 3d ,出血停止后均予以雷尼替丁 30 0mg ,po ,qd维持。结果 :泮托拉唑治疗组有效率 92 % ,止血时间 (1.6±0 .5 )d ,再出血率 3% ,明显优于雷尼替丁对照组[分别为 6 7% ,(2 .5± 0 .6 )d和 2 0 % ],均P <0 .0 5。结论 :静脉滴注泮托拉唑是治疗急性上消化道出血有效、安全的药物 ,尤其适用于中、重度出血的病人 Objective: To observe the efficacy of intravenous infusion of pantoprazole in the treatment of acute upper gastrointestinal bleeding. Methods: 70 patients were divided into 2 groups: pantoprazole group 40 cases, intravenous infusion of pantoprazole 40mg, q 12h, continued 2 ~ 3d, were stopped after bleeding pantoprazole capsule 4 0mg, po, qd maintained. 30 cases of ranitidine control group received intravenous ranitidine 15 0 ~ 200 mg, q 12h for 2 ~ 3d, ranostatin 30Omg, po, qd after stopping of bleeding were maintained. Results: The pantoprazole treatment group was 92% effective, the bleeding time was 1.6 ± 0.5 days and the rebleeding rate was 3%, which was significantly better than that of ranitidine control group [67% (2.5% ± 0 .6) d and 20%], all P <0. Conclusion: Intravenous infusion of pantoprazole is an effective and safe drug for the treatment of acute upper gastrointestinal bleeding, especially for moderate and severe bleeding patients