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目的探讨抗心磷脂抗体(ACA)与脑出血关系,为脑出血早期病情变化机制和脑出血免疫治疗提供新的观点。方法应用酶联免疫吸附(ELISA)法对101例健康人,271例脑出血病人发病1～3 h、24 h、14 d检测ACA(IgG、IgA、IgM)水平。结果脑出血组ACA阳性率(43.91%)高于健康组(12.87%),差异有统计学意义(P<0.01)。脑出血组随着病情加重ACA阳性率逐渐增高,随发病时间的延长ACA阳性率逐渐减少,差异有统计学意义(P<0.05,P<0.01),与IgA、IgM相比IgG更为敏感(P<0.01)。结论 ACA与脑出血病情程度呈正相关,ACA可作为评价脑出血病情程度的重要指标,其中IgG ACA最为敏感,免疫机制可能在脑出血早期病理变化机制中扮演重要角色。
Objective To investigate the relationship between anti-cardiolipin antibodies (ACA) and intracerebral hemorrhage (ICH) and to provide a new perspective for the mechanism of ICH and immune therapy of ICH. Methods Serum levels of ACA (IgG, IgA and IgM) were detected in 101 healthy individuals and 271 patients with cerebral hemorrhage by enzyme-linked immunosorbent assay (ELISA) 1 to 3 hours, 24 hours and 14 days respectively. Results The positive rate of ACA in cerebral hemorrhage group (43.91%) was higher than that in healthy group (12.87%), the difference was statistically significant (P <0.01). The positive rate of ACA increased gradually with the aggravation of illness in the ICH group. The positive rate of ACA gradually decreased with the increase of the onset time, the difference was statistically significant (P <0.05, P <0.01), IgG was more sensitive than IgA and IgM P <0.01). Conclusions ACA is positively correlated with the severity of ICH. ACA can be used as an important index to evaluate the severity of ICH. IgG ACA is the most sensitive and immune mechanism may play an important role in the pathogenesis of early cerebral hemorrhage.