阻断冠脉血流数分内,心肌细胞跨膜电位即发生明显变化,表现为静息电位降低、动作电位振幅减小、数期最大上升速度减慢、平台期缩短甚至消失和动作电位时程缩短等,这是引起传导障碍和不应期离散,进而导致折返性心律失常的直接原因。目前认为,上述变化主要是由于缺氧引起的代谢障碍和失去血流“冲洗作用”(wash—out) Interruption of coronary blood flow within a few minutes, myocardial cells transmembrane potential that significant changes occur, the performance decreased resting potential, the amplitude of action potential decreases, the maximum number of stages of the rate of increase slowed down, plateau or even disappear and the action potential Shorten the process, which is the direct cause of conduction disorders and refractory period dispersion, leading to reentrant arrhythmia. Currently, the above changes are mainly due to hypoxia-induced metabolic disorders and loss of blood flow “wash-out”