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目的:探讨君子扶正汤联合XELOX化疗对局部进展期结直肠癌患者的疗效及免疫功能的影响。方法:根据患者意愿将2013年6月~2015年12月在我院接受治疗92例局部进展期结直肠癌患者分为两组,对照组46例给予XELOX化疗,治疗组46例在对照组的治疗基础上加用君子扶正汤,所有患者连续治疗4个疗程,2周为1个疗程。对各组治疗后的临床疗效及生活质量进行评价,观察两组治疗前后CD3~+、CD4~+、CD8~+及CD4~+/CD8~+比值的变化,记录治疗期间化疗毒反应发生情况。结果:治疗后,治疗组的临床治疗总有效率为78.26%,显著高于对照组的58.70%;对照组治疗后KPS评分改善率为69.57%,治疗组改善率为86.96%;对照组治疗前后CD3~+、CD4~+、CD8~+和CD4~+/CD8~+的变化无统计学差异,治疗组治疗后CD3~+、CD4~+和CD4~+/CD8~+显著升高,CD8~+显著下降;治疗组在治疗过程中恶心呕吐、胃肠道不适及白细胞减少的发生率均显著低于对照组。结论:君子扶正汤联合XELOX化疗治疗局部进展期结直肠癌的疗效显著优于能够优于单独XELOX化疗,能够明显改善患者生活质量,增强免疫功能,且显著减少毒副反应的发生。
Objective: To investigate the effect of Junzifuzheng Decoction combined with XELOX chemotherapy on the efficacy and immune function of patients with locally advanced colorectal cancer. Methods: According to the wishes of the patients, 92 patients with locally advanced colorectal cancer who were treated in our hospital from June 2013 to December 2015 were divided into two groups. 46 patients in the control group were treated with XELOX chemotherapy and 46 patients in the control group On the basis of treatment plus gentleman righting soup, all patients continuous treatment of 4 courses, 2 weeks for a course of treatment. The clinical efficacy and quality of life of each group after treatment were evaluated. The changes of CD3 ~ +, CD4 ~ +, CD8 ~ + and CD4 ~ + / CD8 ~ + ratio before and after treatment were observed and the occurrence of chemotherapy toxicity during the treatment . Results: After treatment, the total effective rate of clinical treatment in the treatment group was 78.26%, which was significantly higher than that in the control group (58.70%). The improvement rate of KPS score was 69.57% in the control group and 86.96% in the treatment group The changes of CD3 ~ +, CD4 ~ +, CD8 ~ + and CD4 ~ + / CD8 ~ + were not significantly different in the treatment group. The levels of CD3 +, CD4 + and CD4 + / CD8 + ~ + Decreased significantly; the treatment group in the course of treatment of nausea and vomiting, gastrointestinal discomfort and the incidence of leukopenia were significantly lower than the control group. Conclusion: The treatment of local advanced colorectal cancer by gentlemen ’s help soup combined with XELOX chemotherapy is superior to that of XELOX chemotherapy alone, which can significantly improve the quality of life and immune function of patients and significantly reduce the incidence of toxic and side effects.