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目的对续随子Euphorbialathyris的种子千金子进行化学成分的研究。方法采用正反相硅胶柱色谱、凝胶柱色谱和重结晶方法进行分离和纯化,通过理化常数和波谱分析对化合物结构进行鉴定。结果从千金子乙醇提取物中分离得到结构类型多样的22个化合物,分别是大戟因子L1[euphobia L1,3-O-苯乙酰基-5,15-O-二乙酰基-6(17)-环氧续随子醇,1]、3,7-O-二苯甲酰基-5,15-O-二乙酰基-7-羟基续随子醇(2)、3-O-苯甲酰基-5,15-O-二乙酰基续随子醇(3)、3-O-十六碳酰基巨大戟醇(4)、20-O-十六碳酰基巨大戟醇(5)、3-O-肉桂酰基-15,17-O-二乙酰基-17-羟基交京大戟醇(6)、3-O-苯甲酰基-5,15,17-O-三乙酰基-17-羟基异续随子醇(7)、3-O-烟酰基-5,15-O-二乙酰基续随子醇(8)、3-O-苯甲酰基-5,15-O-二乙酰基-7-O-烟酰基-7-羟基续随子醇(9)、巨大戟醇(10)、续随子醇(11)、七叶树内酯(12)、β-谷甾醇(13)、棕榈酸(14)、1,2,3-三羟基苯(15)、2,3-二羟丙基十九碳酸酯(16)、2,3-二羟丙基-9-烯-十八碳酸酯(17)、2,3,4-三羟基丁基-十五碳-3-烯碳酸酯(18)、金色酰胺醇脂(19)、苯甲酸(20)、对羟基苯甲酸(21)、油酸(22)。结论其中化合物10、11、14~19是首次从千金子中分离得到。化合物1~3是其主要二萜成分。
Objective To study the chemical composition of the seeds of Euphorbialathyris, which is the sequel to the mate. Methods The compounds were isolated and purified by reverse phase silica gel column chromatography, gel column chromatography and recrystallization method. The structures of the compounds were identified by physicochemical constants and spectral analysis. RESULTS: Twenty-two compounds with different structure types were isolated from ethanol extracts of L. japonicum. They were L. euphobia L1,3-O-phenylacetyl-5,15-O-diacetyl-6(17). -Epoxycontin-2-ol, 1], 3,7-O-dibenzoyl-5,15-O-diacetyl-7-hydroxycontaminate (2), 3-O-benzoyl -5,15-O-Diacetylcontinal (3), 3-O-hexadecanoic (4), 20-O-hexadecanoic (5), 3- O-Cinnamoyl-15,17-O-Diacetyl-17-Hydroxystilbeneol (6), 3-O-Benzoyl-5,15,17-O-Triacetyl-17-Hydroxy Isosterol (7), 3-O-nicotinoyl-5,15-O-diacetylcontinal (8), 3-O-benzoyl-5, 15-O-diacetyl -7-O-nicotinoyl-7-hydroxy continuum alcohol (9), eucalyptus alcohol (10), continuum alcohol (11), esculetin (12), β-sitosterol (13) , palmitic acid (14), 1,2,3-trihydroxybenzene (15), 2,3-dihydroxypropyl nonadecanoate (16), 2,3-dihydroxypropyl-9-ene-deca Octadecanoic acid ester (17), 2,3,4-trihydroxybutyl-pentadec-3-ene carbonate (18), gold amide alcohol ester (19), benzoic acid (20), p-hydroxybenzoic acid ( 21) Oleic acid (22). Conclusion Compounds 10, 11 and 14-19 were isolated from Qianjin for the first time. Compounds 1-3 are the main diterpenoids.