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目的了解免疫接种后发生的不良反应事件与接种本身有无因果关系及判断因果关系的标准。方法收集资料,应用GAVS评价疫苗有害事件因果关系的基本标准进行实例判定。结果在4个实例中,2例不符合GAVS评价疫苗有害事件因果关系的基本标准,不具有因果关系,另2例符合判断标准,但由于其中一例接种的为麻疹减毒活疫苗,亦有可能为偶合病例或为疫苗病例,不能判定为疫苗接种后引起的不良反应。结论通过以上实例的分析,可以看出,有些预防接种有害事件并不需要满足所有的判定标准,就能确定与疫苗接种之间的因果关系;但有些有害事件虽符合多个判定标准,并且进行了实验室特异性指标的测定,仍然很难确定与疫苗之间的因果关系,尤其是在接种了减毒活疫苗,如脊髓灰质炎疫苗和麻疹疫苗时出现的迟缓性麻痹和麻疹病例。
Objective To understand the causal relationship between adverse events after vaccination and vaccination itself and to determine the causal relationship between the two. Methods The data were collected and the cases were judged by using the basic standards of GAVS to evaluate the causality of vaccine adverse events. Results Of the 4 cases, 2 cases did not meet the basic criteria of GAVS to evaluate causality of vaccine adverse events, and did not have a causal relationship. The other 2 cases met the criteria for judgment, but as one of the cases was live attenuated measles vaccine, it is also possible For cases of conjugation or vaccination, adverse reactions caused by the vaccination can not be judged. Conclusion Through the analysis of the above examples, we can see that some vaccination harmful events do not need to meet all the criteria to determine the causal relationship with vaccination; However, although some harmful events meet multiple criteria and conduct Laboratory-specific determination of the indicators still makes it difficult to determine the causal link with the vaccine, especially in the case of delayed paralysis and measles that have been vaccinated with attenuated live vaccines, such as poliomyelitis and measles.