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目的探讨晚期卵巢上皮性癌腹腔化疗的疗效,毒副反应及对患者长期生存的影响。方法对2000年1月-2004年1月在我院治疗的晚期卵巢上皮性癌患者184例,根据术后不同化疗途径分为静脉化疗组(IVC)和腹腔化疗组(IPC)。两组化疗方案相同:紫彬醇+顺铂。均给予6～8个疗程化疗,疗程结束后评价疗效,比较两组的毒副反应、疗效和预后。结果IPC组和IVC组有效率分别为92.6%和87.6%,两组比较差异无统计学意义(P>0.05),复发率:IPC组为48.9%,IVC组为60.3%,两组比较差异无统计学意义(P>0.05),复发时间:IPC组24个月,IVC组18个月,两组比较差异有统计学意义(P<0.05),毒副反应中化学性静脉炎发生率:IPC组为10.7%,IVC组为33.7%,两组比较差异有统计学意义(P<0.05),其他毒副反应两组间比较差异均无统计学意义。结论腹腔化疗并不能提高晚期卵巢上皮性癌的疗效,但能够延长其复发时间,临床应用时仍有一定的局限性。
Objective To investigate the efficacy, side effects and long-term survival of patients with advanced ovarian epithelial carcinoma treated by intraperitoneal chemotherapy. Methods 184 patients with advanced ovarian epithelial carcinoma treated in our hospital from January 2000 to January 2004 were divided into intravenous chemotherapy group (IVC) and intraperitoneal chemotherapy group (IPC) according to different postoperative chemotherapy regimens. Two groups of chemotherapy the same: purple Bin alcohol + cisplatin. Were given 6 to 8 courses of chemotherapy, after the end of treatment evaluation of efficacy, compare the two groups of side effects, efficacy and prognosis. Results The effective rates of IPC group and IVC group were 92.6% and 87.6%, respectively. There was no significant difference between the two groups (P> 0.05). The recurrence rate was 48.9% in IPC group and 60.3% in IVC group The recurrence time was 24 months in IPC group and 18 months in IVC group, the difference was statistically significant (P <0.05), the incidence of chemical phlebitis in IPC was Group was 10.7%, IVC group was 33.7%, the difference between the two groups was statistically significant (P <0.05), the other side effects were no significant difference between the two groups. Conclusion Intraperitoneal chemotherapy can not improve the efficacy of advanced epithelial ovarian cancer, but can prolong the recurrence time, there are still some limitations in clinical application.