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乙型肾上腺素能阻滞剂治疗心绞痛有效,但此类药物具有负性肌力作用,故非所有冠心病患者均可获益,因而需要继续寻找其他治疗心绞痛的药物。异速搏停(Verapamil)是一种罂粟硷的衍生物,它在实验动物中具有扩张冠状动脉的性能。在人类,异速搏停的一个重要作用是增强迷走神经张力对心脏特殊传导组织的效应。异速搏停治疗心肌缺血的结果各人报导互有矛盾,因而促使作者进行此项比较试验。作者用异速搏停、心得安、二硝酸异山梨醇(Isosorbide dinitrate)和安慰剂治疗了32例心绞痛患者。其中男性25例,平均年龄52.2岁;女性7例,平
Beta-adrenergic blockers are effective in the treatment of angina pectoris, but these drugs have negative inotropic effects and therefore may benefit all patients with coronary heart disease. Therefore, other drugs for the treatment of angina need to be continuously searched. Verapamil is a papaverine derivative that has the property of dilating coronary arteries in experimental animals. In humans, an important role for isokinetic arrest is to increase the effect of vagal tone on the heart’s specific conduction tissue. Different speed beat stop treatment of myocardial ischemia results reported by each conflicting, thus prompting the author to carry out this comparative test. The authors treated 32 angina patients with allostauon, propranolol, Isosorbide dinitrate and placebo. Including 25 males, mean age 52.2 years; 7 females, flat