高分子键合康普瑞汀A4血管阻断剂纳米药物

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血管阻断剂(VDAs)因其在实体肿瘤治疗中的巨大潜力而引起人们的广泛关注.本文针对本课题组近年来在高分子血管阻断剂纳米药物抗肿瘤治疗方面的基础研究进行了总结.首先发现了纳米药物的瘤内低渗透性可显著提高血管阻断剂的肿瘤血管靶向性和抑瘤能力,进而构建了高分子血管阻断剂纳米药物;其次针对高分子血管阻断剂纳米药物治疗所引起的不利宿主反应,引入小分子抑制剂或激动剂进行联合治疗;然后利用其调控肿瘤微环境并创建肿瘤选择性药物激活递送系统;最后针对其治疗所产生的肿瘤凝血微环境提出了新的主动靶向策略——链式自放大肿瘤靶向,实现了高效的肿瘤靶向药物递送.这项工作突出了高分子血管阻断剂纳米药物在肿瘤治疗中的潜力,并对其未来研究方向作了简要展望,以促进其临床转化.
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1引 言 rn1.1背景简介rn设A ∈Rn×n为n阶实对称矩阵,矩阵A的特征值分解是找正交矩阵U ∈Rn×n,使得rnA=UΛUT,(1.1)rn其中UT指U的转置,A为对角矩阵,且A=diag(λ1,λ2,...,λn),其中λi,i=1,...,n是矩阵A的特征值.矩阵A的奇异值分解为rnA=UΣUH,(1.2)rn其中,U ∈ Cn×n是酉矩阵,UH是U的共轭转置,Σ是非负实对角矩阵.当A正定时,奇异值分解和特征值分解等价.对一般实对称阵,奇异值和特征值绝对值相同.
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