论文部分内容阅读
目的探讨患者眼部真菌感染的体外药物敏感性临床应用,为合理使用抗菌药物提供参考依据。方法收集医院2012年3月-2014年12月患者眼部标本80份,将标本接种在萨布罗培养基,采用纸片法分析常用抗菌药物对培养阳性真菌的敏感性,数据采用SPSS 17.0软件进行统计分析。结果 80例标本中真菌培养阳性20例,阳性率为25.0%;共培养出20株真菌,以镰刀菌属为主,共8株占40.0%;镰刀菌属对那他霉素敏感性较高,对两性霉素B、氟康唑、伊曲康唑及特比萘芬的敏感性低,均<26.0%。结论在对眼部真菌感染最为主要的是曲霉菌属以及镰刀菌属,镰刀菌属对两性霉素B、氟康唑、伊曲康唑以及特比萘芬的敏感性低于对那他霉素的敏感性,曲霉菌属对那他霉素、伊曲康唑、氟康唑以及两性霉素B的敏感性低于对特比萘芬的敏感性。
Objective To investigate the clinical application of in vitro drug sensitivity to ocular fungal infection in patients and provide a reference for rational use of antibacterial drugs. Methods Eighty eyes of the patients in the hospital from March 2012 to December 2014 were collected. The specimens were inoculated on the Sabro medium, and the sensitivity of the commonly used antibiotics to the culture positive fungi was analyzed by the paper method. The data were analyzed by SPSS 17.0 software conduct statistical analysis. Results Totally 20 fungi were cultured in 80 samples, the positive rate was 25.0%. 20 fungi were co-cultivated, mainly Fusarium and 8 were 40.0%. Fusarium was more sensitive to natamycin , With low sensitivity to amphotericin B, fluconazole, itraconazole and terbinafine, both <26.0%. CONCLUSIONS Aspergillus and Fusarium species are the most prominent contributors to ocular fungal infections and are less susceptible to amphotericin B, fluconazole, itraconazole, and terbinafine than those against natto The sensitivities of Aspergillus to natamycin, itraconazole, fluconazole and amphotericin B are less sensitive than terbinafine.