类风湿关节炎(rheumatoid arthritis,RA)是一种以慢性、进行性、侵袭性关节炎为主要表现的全身性自身免疫疾病[1],患病5~10年致残而使患者丧失劳动能力比例达33%~39%[2],是我国肢体残疾的主要致残因素之一[3]。其高度骨破坏过程所导致的局灶性骨侵蚀与关节功能丧失等不良预后密切相关[4],因此RA以保护关节、减轻骨破坏为治疗目标。近年来有较多清热活血类方药治疗RA及RA相关骨破坏的临 Rheumatoid arthritis (RA) is a systemic autoimmune disease mainly characterized by chronic, progressive and aggressive arthritis [1], which causes the disabled to work after 5 to 10 years of disability The proportion of 33% to 39% [2], is one of the main disability physical disability factors [3]. Its high degree of bone destruction caused by the process of focal erosion and loss of joint function is closely related to poor prognosis [4], so RA to protect the joints, reduce bone destruction as the treatment goal. In recent years, there are more hot and blood type prescription drugs to treat RA and RA-related bone destruction