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目的探讨妇女淋病奈瑟菌(NG)、沙眼衣原体(CT)、解脲脲原体(UU)感染与不孕症的关系。方法选取2013年1月-2014年1月在该院妇科门诊就诊的168例不孕症[包括原发性不孕95例(作为原发性不孕组),继发性不孕73例(作为继发性不孕组)]患者为研究对象(作为不孕组),另选取150例正常孕妇为对照组,采用PCR扩增法检查2组NG、CT、UU等病原学特征。结果不孕组NG、CT、UU阳性率(50.60%、58.33%、60.71%)显著高于对照组(5.33%、6.67%、8.00%),差异有统计学意义(χ~2=78.456、94.320、103.49,P<0.05)。继发性不孕组与原发性不孕组NG、CT、UU阳性率(54.79%、63.01%、60.27%;47.37%、54.74%、61.05%)差异无统计学意义(χ~2=0.911、1.163、0.010,P>0.05)。经药物治疗后,对患者随访1年,合并3种感染者累计妊娠率(9.09%)显著低于合并2种感染者(26.32%)或合并1种感染者(44.12%),而合并2种感染者累计妊娠率(26.32%)低于合并1种感染者(44.12%),差异有统计学意义(χ~2=10.285,P<0.05)。结论 NG、CT、UU感染与不孕症有密切的关系,因此加强对育龄妇女NG、CT、UU筛查具有重要的意义。
Objective To investigate the relationship between Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Uu infection in women with infertility. Methods A total of 168 infertility patients (including 95 cases of primary infertility as primary infertility group) and 73 cases of secondary infertility (secondary infertility group) were selected from January 2013 to January 2014 in our gynecological clinic. As secondary infertility group)] were selected as study subjects (as infertility group). Another 150 normal pregnant women were selected as control group. The etiological characteristics of NG, CT and UU were examined by PCR. Results The positive rates of NG, CT and UU in infertility group (50.60%, 58.33%, 60.71%) were significantly higher than those in control group (5.33%, 6.67%, 8.00%), the difference was statistically significant (χ ~ 2 = 78.456,94.320 , 103.49, P <0.05). The positive rates of NG, CT and UU in secondary infertility group and primary infertility group were 54.79%, 63.01%, 60.27%, 47.37%, 54.74% and 61.05%, respectively (χ ~ 2 = 0.911 , 1.163,0.010, P> 0.05). After drug treatment, the patients were followed up for 1 year. The cumulative pregnancy rate (9.09%) was significantly lower than those with two kinds of infection (26.32%) or with one kind of infection (44.12%), The cumulative pregnancy rate of infected persons (26.32%) was lower than that of one infected person (44.12%) (χ ~ 2 = 10.285, P <0.05). Conclusion The infection of NG, CT and UU is closely related to infertility, so it is of great significance to strengthen the screening of NG, CT and UU in women of childbearing age.