近期分子生物学的进展大大加速了有关胆盐肠肝循环意义的认识。约 5 0 %的胆固醇通过分解代谢成胆酸而降解 ,转而为类脂的吸收所需要。早已知道回肠切除可引起脂肪吸收不良 ,由于缺乏回肠吸收足够胆盐的缘故 ,大量胆盐的丧失可加速胆固醇肝内分解成胆盐而导致血清胆固醇的降低 Recent advances in molecular biology have greatly accelerated the understanding of the significance of bile-salt enterohepatic circulation. Approximately 50% of the cholesterol is degraded by catabolism to bile acid, which in turn is required for lipid absorption. It has long been known that ileal resection can cause poor malabsorption of fat. Due to lack of ileum to absorb enough bile salts, the loss of a large amount of bile salt can accelerate the decomposition of cholesterol into bile salts, which leads to the decrease of serum cholesterol