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丙戊酸（VPA）是临床上常用的广谱抗癫痫药物，它在血浆中大部分与血浆蛋白结合，结合率85～95％，只有其非结合部分（游离部分）才能透过血脑屏障进入脑内发挥药理作用。一般情况下，血浆中VPA游离浓度与脑脊液（CSF）及脑组织中的浓度是一致的。进入脑内VPA的量直接关系到该药的治疗效果，传统的方法是加大VPA的投药量以增高血浓度，从而提高CSF及脑组织的药水平，但这也增加了VPA副作用的发生。
Valproic acid (VPA) is a widely used broad-spectrum antiepileptic drug in clinical practice. It is mostly bound to plasma proteins in the plasma with a binding rate of 85-95%. Only the non-binding part (free part) can cross the blood-brain barrier Into the brain to play a pharmacological effect. In general, the plasma VPA free concentration is consistent with the concentration in cerebrospinal fluid (CSF) and brain tissue. The amount of VPA entering the brain is directly related to the therapeutic effect of the drug. The traditional method is to increase the dosage of VPA to increase the blood concentration, thereby increasing the CSF and brain tissue drug levels, but this also increases the incidence of VPA side effects.