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目的观察普贝生用于足月引产的临床效果及其安全性。方法将120例妊娠足月、宫颈Bishop评分≤5分、有阴道分娩适应证、无引产禁忌证的单胎头位初产妇随机分为2组:60例将普贝生1枚(10mg)置于阴道后穹窿作为实验组,若无不良反应,12h后取出;60例给予硫酸普拉酮钠200mg/d静脉推注3d作为对照组。比较2组产妇用药前及用药后12h的宫颈Bishop评分、临产情况、剖宫产率、对胎儿及新生儿的影响。结果用药12h后,实验组有51例宫颈评分提高≥2分,有效率为85%;而对照组未次用药12h后有9例宫颈评分提高≥2分,有效率仅为15%。2组间差异有统计学意义(P<0.01);24h内实验组70%(42/60)的孕妇临产,对照组6.6%(4/60)的孕妇临产,2组间差异有统计学意义显著性(P<0.01);实验组65%(39/600)的孕妇经阴道分娩,对照组41.7%(25/60)的孕妇经阴道分娩,2组间差异有统计学意义显著性(P<0.05);2组间胎儿窘迫发生率、新生儿Apgar评分均差异无统计学意义(P>0.05)。结论普贝生能够有效促进宫颈成熟,引产成功率高,不良反应少,可以较安全用于临床。
Objective To observe the clinical effect and safety of pubey in induction of term labor. Methods 120 cases of gestational term, cervical Bishop score ≤ 5 points, indications of vaginal delivery, abortion contraindications of single-head primiparous were randomly divided into two groups: 60 cases of Pubei 1 (10mg) set In the vaginal posterior fornix as the experimental group, if no adverse reaction, remove after 12h; 60 patients were given intravenous injection of 200mg / day pramoxi sulphate sodium as control group. The Bishop cervical score, labor status, cesarean section rate before and 12h after treatment were compared between the two groups on the fetus and newborn. Results After 12 hours of treatment, 51 cases of cervical score increased by 2 points in the experimental group, the effective rate was 85%; while in the control group, 9 cases of cervical score increased by 2 points after 12 hours of no administration, the effective rate was only 15%. The difference was statistically significant between the two groups (P <0.01). In the experimental group, 70% (42/60) of the pregnant women gave birth in 24 hours, and 6.6% (4/60) of the pregnant women in the control group gave birth. There was significant difference between the two groups (P <0.01). In the experimental group, 65% (39/600) pregnant women delivered vaginally and 41.7% (25/60) pregnant women in the control group delivered vaginally. The difference between the two groups was statistically significant (P <0.05). There was no significant difference between the two groups in the incidence of fetal distress and neonatal Apgar scores (P> 0.05). Conclusion Pu Bei Sheng can effectively promote cervical maturation, high success rate of induction of labor, fewer adverse reactions, can be more safely used in clinical practice.