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海星胶代血浆经动物实验和临床试用,表明抗休克效果好,且无毒性。为了进一步评价海星胶代血浆作为血容扩张剂的功效,我们利用同位素示踪法观察了它在动物体内的存留时间和排泄途径,现报告如下: 材料和方法 ~(131)Ⅰ-海星胶的制备以氯胺T为氧化剂,用~(131)Ⅰ-标记得之。示踪剂量为15微居里/公斤体重。按照示踪所需的放射性总强度和所需输注的海星胶代血浆总体积,将标记的海星胶和非标记的3％海星胶液(内含0.9％氯化钠)适当比例混合配制成~(131)Ⅰ-海星胶代血浆。选择三只雄性、成年、健康杂种狗为实验动物,体重在16.4—17.5公斤,沿用先前的方法将狗造成失血性休克,然后立即由股静脉输入等体积~(131)Ⅰ-海星胶代血浆,有关情况见表1。
Starfish gel on behalf of the plasma animal experiments and clinical trials show that anti-shock effect, and non-toxic. In order to further evaluate the efficacy of starfish gelatin on blood plasma as a vasodilator, we used isotope tracer method to observe its survival time and excretion in animals. It is reported as follows: Materials and Methods ~ (131) I- Preparation of chloramine T as oxidant, with ~ (131) Ⅰ-labeled. The tracer dose is 15 mcg / kg body weight. According to the total radioactivity required for tracing and the total plasma volume of the starfish gel transfused, the labeled starfish gum and the non-labeled 3% starfish glue (containing 0.9% sodium chloride) are mixed in the proper proportions ~ (131) Ⅰ-starfish gel on behalf of the plasma. Three male, adult, and healthy mongrel dogs were selected as test animals and weighed 16.4-17.5 kg. The dogs were hemorrhagic shocked by the previous method. Immediately thereafter, an equal volume of (131) I- , The situation is shown in Table 1.