本文用电感耦合等离子体质谱法测定了人体血浆中的稀土元素。在优化的条件下 ,以内标法测得的各种纯水溶液的检测限在 0 .7(Eu)～ 5 .4(Gd) ng·L- 1范围内。研究了 K,Na,Ca,Fe等基体元素对稀土测定的影响。以 In为内标元素补偿样品基体效应以及灵敏度飘移。比较了直接稀释、HNO3- H2 O2 消解及 HNO3-HCl O4消解 3种样品处理方法 ,用 1% HNO3直接稀释样品可满足轻稀土元素的定量分析要求 ,方法的定量测定下限≤ 1μg·L- 1。 In this paper, the determination of rare earth elements in human plasma by inductively coupled plasma mass spectrometry. Under optimal conditions, the detection limit of various pure water solutions measured by internal standard method was in the range of 0 .7 (Eu) ~ 5.4 (Gd) ng · L -1. The effects of K, Na, Ca, Fe and other matrix elements on the determination of rare earths were studied. The In-element is used to compensate for the matrix effect and the drift of sensitivity. The methods of direct dilution, HNO3-H2O2 digestion and HNO3-HCl O4 digestion were compared, and the sample was directly diluted with 1% HNO3 to meet the quantitative analysis of light rare earth elements. The lower limit of quantification was 1μg · L -1 .