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目的观察前列地尔注射剂(PGE1,商品名凯时,北京泰德制药有限公司生产)治疗慢性肾衰竭的效果。方法将82例慢性肾衰竭患者随机分为两组。治疗组42例在常规治疗基础上加用凯时10μg,静滴,1次/d,2周为一个疗程;对照组给予常规治疗,包括控制血压、血糖等处理。观察血尿素氮、肌酐、尿酸及24 h尿蛋白定量等变化。结果治疗组血尿素氮、肌酐、尿量、尿酸及24 h尿蛋白定量治疗后较治疗前有明显下降(P<0.05),而对照组治疗后较治疗前尿量和24 h尿蛋白下降(P<0.05),但差异有统计学意义(P<0.05),治疗组和对照组在尿酸、尿量和24 h尿蛋白比较有显著差异(P<0.01)。结论前列地尔注射剂可以进一步改善慢性肾衰竭患者的肾功能。
Objective To observe the effect of prostaglandin injection (PGE1, trade name Kay, Beijing Ted Pharmaceutical Co., Ltd.) in the treatment of chronic renal failure. Methods 82 patients with chronic renal failure were randomly divided into two groups. In the treatment group, 42 cases were treated with Kai 10 g, intravenous infusion, once / d for 2 weeks on the basis of routine treatment. The control group received routine treatment including blood pressure control and blood sugar control. Blood urea nitrogen, creatinine, uric acid and 24 h urinary protein were measured. Results The levels of blood urea nitrogen, creatinine, urine volume, uric acid and 24 h urine protein in the treatment group were significantly lower than those before treatment (P <0.05), while those in the control group were significantly lower than those before treatment P <0.05), but the difference was statistically significant (P <0.05). There was significant difference between the treatment group and the control group in urine uric acid, urine output and 24 h urine protein (P <0.01). Conclusion Alprostadil injection can further improve renal function in patients with chronic renal failure.