:尿频康 5～ 2 0 g/ kg灌胃给药 ,对正常、水负荷和注射速尿后大、小鼠的排尿均有抑制作用。表现为1h内的排尿次数、排尿量减少。口服 0 .5h起效 ,1h达高峰 ,持续时间 7h。尿频康体内过程呈二室模型 ,2 h前为分布相 ,2 h后为消除相。效量半衰期 [t1/ 2 ( ED) ],α相为 0 .737h,β相为 5.4 2 8h。表观半衰期 α相 0 .82 7h,β相5.84 7h : Urinary frequency 5 ~ 20 g / kg intragastric administration, inhibition of normal, water load and after injection of furosemide, mice urinating are inhibited. The number of urination and urine output decreased within 1 hour. Oral 0. 5h onset, 1h peak, duration 7h. The internal course of urinary frequency was a two-compartment model, with a distribution phase 2 h before and a phase elimination 2 h later. The half-life of the effect [t1/ 2 (ED) ], α phase is 0.737h, β phase is 5.4 2 8h. Apparent half-life α phase 0.72 7h, β phase 5.84 7h