论文部分内容阅读
对２５例胆囊粘膜异型增生和４０例胆囊腺癌标本用免疫组化方法观察ｂｃｌ２和ｐ１６蛋白的表达，并与正常胆囊粘膜比较。结果：在正常胆囊粘膜中均未见ｂｃｌ２和ｐ１６表达，而胆囊粘膜上皮异型增生及胆囊腺癌组织中，两者的表达阳性率较正常组织明显增高（Ｐ＜０．０１），且ｂｃｌ２和ｐ１６蛋白的阳性率随着异型增生程度的增高而增加；ｐ１６的表达还与胆囊腺癌之浸润程度及淋巴结转移有关。本实验结果提示：ｂｃｌ２及ｐ１６蛋白表达在胆囊腺癌和胆囊粘膜异型增生中起了一定作用；ｐ１６可作为胆囊癌患者的一个预后指标。
Twenty-five cases of gallbladder dysplasia and 40 cases of gallbladder adenocarcinoma were examined for the expression of bcl-2 and p16 protein by immunohistochemistry and compared with normal gallbladder mucosa. RESULTS: No expression of bcl-2 and p16 was found in normal gallbladder mucosa, but the positive rate of both gallbladder epithelial dysplasia and gallbladder adenocarcinoma was significantly higher than that of normal tissues (P<0.01). The positive rate of bcl 2 and p16 protein increased with the degree of dysplasia; the expression of p16 was also related to the degree of invasion of gallbladder adenocarcinoma and lymph node metastasis. The results of this experiment suggest that the expression of bcl-2 and p16 proteins plays a role in gallbladder adenocarcinoma and dysplasia of gallbladder mucosa; p16 can be used as a prognostic indicator in gallbladder cancer patients.