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用聚合酶链式反应──限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）技术检测８例胃癌及１例正常胃组织Ｐ５３基因第２４９密码子点突变，结果未发现异常，提示Ｐ５３基因第７外显子第２４９密码子点突变不是本地区胃癌Ｐ５３基因突变的常见类型。
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect the point mutation of the 249 codon of P53 gene in 8 cases of gastric cancer and 1 case of normal gastric tissue. No abnormal result was found, suggesting that P53 gene No. 7 The exon 249 codon mutation in exon is not a common type of P53 mutation in gastric cancer in this region.