目的:探讨中孕期产前筛查网络化运作方法。方法:市卫生局结合有关法律法规制定适宜的管理办法、技术规范,成立泰安市疾病筛查中心,具体负责产前筛查、产前诊断和新生儿疾病筛查,各项技术获得执业许可;充分利用妇幼网络,组建筛查三级网;通过电视、专题光盘、彩页、下乡讲课等广泛宣传,免费培训相关业务人员;对孕前及早、中孕期保健的夫妇书面告知签字,中孕期知情选择筛查;样本采集后立即分离冰冻、专用冷链箱递送、严格验收交接,采取中孕期二联筛查,每板检测设高中低室内质控物、每年参加卫生部室间质评,发现问题及时整改;孕妇信息录入前后认真核实、转换阴历日期,报告单审核、登记、签字发放;高风险孕妇按计划通知、预约产前诊断,记录电话内容、同时录音;确诊病例保偿诊断费和普通引产费、假阴性病例一次性保偿人民币3 000元。结果:筛查57 658例,筛查率有0.1%上升到52.8%,市区筛查率达到了97.8%、县市区中最高达到了71.6%;唐氏综合征筛查阳性率5.8%;产前诊断率62.6%,市区最高到99.6%、县市区最高达到了68.3%;合计引产61例。结论:产前筛查是一项多环节、多专业人员参与的系统服务,加强行政干预、严格落实各环节的质量管理,不断提高筛查率和诊断率,以达到降低出生缺陷的目的。 Objective: To explore the prenatal screening network in mid-pregnancy operation method. Methods: The Municipal Health Bureau formulated appropriate management measures and technical specifications in conjunction with the relevant laws and regulations to set up the Taian City Center for Disease Screening, which is specifically responsible for prenatal screening, prenatal diagnosis and neonatal disease screening and obtaining various licenses for practicing various techniques. Make full use of women and children network, set up screening tertiary network; through TV, special disc, color pages, lectures to the countryside and other publicity, free training of business personnel; early pregnancy, early pregnancy, health care couple informed written signature, Select the screening; the samples were collected immediately after freezing, special cold chain box delivery, strict acceptance of the transfer, take the second trimester screening, detection of high and low in each board set the internal quality control material, the Ministry of Health to participate in inter-laboratory quality assessment and found problems Timely rectification; pregnant women before and after the entry information carefully verified, the date of the conversion of lunar calendar, the report single review, registration, signature release; high-risk pregnant women notice according to plan, appointment prenatal diagnosis, record the phone content at the same time recording; Induction of labor costs, false negative cases a one-time payment of 3,000 yuan. Results: 57 658 cases were screened, the screening rate increased from 0.1% to 52.8%, the screening rate in urban areas reached 97.8%, the highest in urban areas reached 71.6%, the Down’s syndrome screening positive rate was 5.8% The prenatal diagnosis rate was 62.6%, the highest in urban areas was 99.6%, and the highest in urban counties reached 68.3%. The total induction of labor was 61 cases. Conclusion: Prenatal screening is a multi-link and multi-professional system service, which strengthens the administrative intervention, strictly implements the quality management in all aspects and continuously improves the screening rate and diagnosis rate so as to reduce the birth defects.