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空肠弯曲菌(CJ-S131)感染昆明(KM)小鼠后15个月,KM小鼠仍然具有并发展了感染后3个月所表现的自身免疫综合征。其表现为抗核抗体阳性;多种自身抗体(抗ds-DNA,ss-DNA,组蛋白,ENA和胸腺细胞抗体)升高;肠淋巴组织增生,胸腺呈纤维化倾向,脾脏、淋巴结肿大;免疫复合物性肾小球肾炎和血管炎;肠道及肠外多器官(肝脏、肺、心脏和唾液腺等)慢性炎症;空弯菌外膜蛋白(CJ-OMP)特异性抗体与自身抗体的消长相背离,随感染时间延长,CJ-OMP抗体阳性百分率下降,抗ds-DNA,ENA和胸腺细胞等抗体的阳性率上升。本文再次证实,慢性空弯菌感染可诱发小鼠自身免疫综合征,而诱发因子特异性抗体随自身免疫综合征的出现而下降。
Fifteen months after infection with Campylobacter jejuni (CJ-S131), KM mice still had and developed an autoimmune syndrome that developed 3 months after infection. It showed a positive anti-nuclear antibody; a variety of autoantibodies (anti-ds-DNA, ss-DNA, histone, ENA and thymocyte antibodies) increased; intestinal lymph node hyperplasia, thymus fibrosis, spleen, lymph nodes ; Immune complex glomerulonephritis and vasculitis; chronic intestinal and extraintestinal organ (liver, lung, heart and salivary gland, etc.) chronic inflammation; empty curved outer bacteria protein (CJ-OMP) specific antibodies and autoantibodies The positive rate of CJ-OMP antibody decreased and the positive rate of anti-ds-DNA, ENA and thymocyte antibodies increased with the extension of infection time. This paper confirms once again that C. aeruginosa infection can induce autoimmune syndrome in mice and that the elicitor-specific antibodies decrease with the appearance of autoimmune syndrome.