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临床实践证明,抗菌素是不能完全代替磺胺的,因后者具有使用方便,抗药性和过敏症不像抗菌素那样严重,价格便宜,易于生产等优点。目前磺胺的研究倾向于长效制剂。1956年第一个长效磺胺——磺胺甲氧基吡噠嗪问世,给继续研究磺胺开辟了新的途径。目前已有数种长效制剂使用于临床,我国也进行了试制,上述长效磺胺上海、北京一些药厂已投入生产,市场也开始供应。本文就较常用的两种长效磺胺作一简介。一、磺胺甲氧基吡噠嗪(Sulfamethoxypyridazine筒称SMP)商品名:Kynex;Lederkyn;Midicel。化学名:3-氨苯磺胺-6-甲氧基吡噠嗪。性状:本品为白色或黄白色结晶性粉末,味苦,无臭或近于无臭。在空气中稳定,但暴露光线下逐渐变暗色。微溶于水,很易溶于鹼性水溶液中,难溶于醇。作用和用途:本品抗菌作用与磺胺嘧啶相似,但作用快,服后在肠道迅速吸收,2-3小时血液中浓度达最高峰。本品血中浓度的有效治疗范围为10-15
Clinical practice has proved that antibiotics can not completely replace sulfonamides, because the latter is easy to use, drug resistance and allergy are not as serious as antibiotics, cheap, easy to produce and so on. The current study of sulfonamides tend to be long-acting formulations. The first long-acting sulfonamide-sulfamethoxypyridazine was introduced in 1956, opening up new avenues for further research on sulfonamides. At present, there are several kinds of long-acting preparations used in clinical trials in our country. The above long-acting sulfonamides have been put into production in Shanghai and some pharmaceutical factories in Beijing have been put into production and the market has begun to supply. This article is more commonly used two long-acting sulfonamides for a brief introduction. First, sulfamethoxypyridazine (Sulfamethoxypyridazine tube SMP) Trade Name: Kynex; Lederkyn; Midicel. Chemical Name: 3-aminobenzenesulfon-6-methoxypyridazine. Traits: This product is white or yellowish white crystalline powder, bitter, odorless or near odorless. Stable in the air, but gradually darken when exposed to light. Slightly soluble in water, easily soluble in alkaline aqueous solution, insoluble in alcohol. Function and use: The antibacterial activity of this product is similar to sulfadiazine, but the effect is fast. After serving, it is rapidly absorbed in the intestine. The concentration reaches the peak in 2-3 hours. This product is an effective treatment of blood concentrations of 10-15