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一些细胞因子和生长因子在肾小球继发性病理发展过程中起关键作用，这提示这些细胞因子和生长因子拮抗剂很可能可以发展成为肾小球疾病临床治疗的有效药物。细胞因子和生长因子拮抗剂有四类：（１）抗细胞因子、生长因子或抗这些因子受体的抗体；（２）可溶性细胞因子或生长用子受体；（３）细胞因子或生长因子受体特导性拮抗剂；（４）其它。已经证实给予一些细胞因子或生长因子拮抗刑的确可以有效地抑制肾小球系膜细胞在体内或体外的增殖以及系膜细胞间质成分的合成与分泌，缀解动物实验模型中肾小球的继发性病理改变，使肾功能得到明显的改善。
Some cytokines and growth factors play a key role in the pathogenesis of glomerular secondary pathology, suggesting that these cytokines and growth factor antagonists are likely to develop into effective agents for the clinical treatment of glomerular diseases. There are four types of cytokines and growth factor antagonists: (1) anti-cytokines, growth factors or antibodies against these receptors; (2) soluble cytokines or growth regulators; (3) cytokines or growth factors Receptor specific antagonist; (4) others. It has been confirmed that antagonism of some cytokines or growth factors can indeed inhibit the proliferation of mesangial cells in vitro or in vivo as well as the synthesis and secretion of mesangial cell interstitial components. Secondary pathological changes, so that renal function was significantly improved.