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目的：观察艾迪注射液联合顺铂与氟尿嘧啶治疗晚期食管癌的临床疗效。方法将46例晚期食管癌患者随机分为观察组（24例）和对照组（22例），观察组给予顺铂30mg／m2，静脉注射，第1～3天，氟尿嘧啶500 mg／m2，静脉注射，第1～5天，28天为1个周期，连用2个周期，化疗同时给予艾迪注射液，50 ml 加入5％葡萄糖注射液500 ml 静脉滴注，每日1次，连用14天。对照组单纯化疗，方案同观察组。结果观察组和对照组近期疗效有效率分别为41．6％和40．9％，无显著性差异（P ＞0．05）。观察组临床症状改善率和KPS 评分提高率显著高于对照组（P ＜0．05），观察组 II 度以上白细胞和血小板减少的发生率显著低于对照组（P ＜0．05）。结论艾迪注射液可以改善晚期食管癌患者的临床症状，减轻化疗的不良反应，提高患者的生活质量，艾迪注射液联合 PF 方案化疗能取得更好的临床收益。“,” Objective To observe the therapeutic efficacy of Aidi injection combined with cisplation and 5 -fluorouracil (PF regimen)chemotherapy in treatment of advanced esophagealcancer.Methods 46 cases of advanced esophageal cancer were divided randomly into two groups.24 patients of test group were treated with Aidi injection (50 ml,d1 ~d14)combined with cisplation (DDP 30mg/m2,d1 ~d3)and 5 -fluorouracil (5 -Fu 500 mg/m2,d1 ~d5).22 patients of control group only received PF Chemotherapy.The therapeutic efficacy of the twogroups was evaluated after two cycles of treatment.Results The overall response rates of test group and control group were 41.6% and 40.9%,there was no statistically significant difference (P>0.05).The symptoms control rate of test group was higher than that of control group (P <0.05).The life quality of patients in test group was superior to the patients in control group (P <0.05).II ~IV degree myelosuppression rate of test group was lower than that of control group (P <0.05).Conclusion Aidi injection has the function of alleviating the symptoms and poisonousside -effect of chemotherapy medicine and improving life quality of patients with advanced esophageal cancer.