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目的探讨儿童重型β-地中海贫血(重型地贫)异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,Allo-HSCT)后出血性膀胱炎(HC)的影响因素。方法对我院儿科造血干细胞移植中心2008年12月～2009年11月儿童重型地贫Allo-HSCT33例病例,进行回顾性分析。结果HC发病率为24.24%(8/33),其中Ⅰ度1例,Ⅱ度6例,Ⅲ度1例。HC的中位时间为22.9(6～35)d,持续的中位时间为11.9(3～27)d。年龄影响HC的发病率(P=0.042,P<0.05);年龄≥6岁的儿童发病率明显高于年龄<6岁儿童。结论儿童重型地贫Allo-HSCT,年龄是HC的主要影响因素。
Objective To investigate the influencing factors of hemorrhagic cystitis (HC) in children with severe β-thalassemia major allogeneic hematopoietic stem cell transplantation (Allo-HSCT). Methods A retrospective analysis was performed on 33 cases of severe thalassemia allo-HSCT in our pediatric hematopoietic stem cell transplantation center from December 2008 to November 2009. Results The incidence of HC was 24.24% (8/33), of which 1 was grade Ⅰ, 6 was grade Ⅱ and 1 was grade Ⅲ. The median time to HC was 22.9 (ranged from 6 to 35) days, with a median duration of 11.9 (range, 3 to 27) days. Age affected the incidence of HC (P = 0.042, P <0.05); the incidence of children aged> 6 years was significantly higher than that of children <6 years of age. Conclusion Allo-HSCT in children with severe thalassemia and age are the main influencing factors of HC.