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目的检测中枢神经系统感染患儿脑脊液超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性的变化,探讨其在中枢神经系统感染诊断中的临床价值。方法采用比色法测定48例化脓性脑膜炎和32例细菌性脑膜炎患儿急性期和恢复前脑脊液中SOD和GSH-PX的活性,并与对照组进行比较分析。结果化脓性脑膜炎组和病毒性脑膜炎组急性期脑脊液SOD和GSH-PX活性显著高于恢复前和对照组(P<0.05);急性期化脓性脑膜炎组脑脊液SOD和GSH-PX活性显著高于病毒性脑炎组(P<0.05)。结论 SOD和GSH-PX活性测定有助于中枢神经系统感染的鉴别诊断及脑损害程度的判断。
Objective To investigate the changes of cerebrospinal fluid superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity in children with central nervous system infection and explore its clinical value in the diagnosis of central nervous system infection. Methods The activity of SOD and GSH-PX in cerebrospinal fluid (CSF) of 48 cases of purulent meningitis and 32 cases of bacterial meningitis were detected by colorimetric method and compared with the control group. Results The activity of SOD and GSH-PX in cerebrospinal fluid in acute purulent meningitis group and viral meningitis group were significantly higher than those in pre-recovery and control groups (P <0.05). The activity of SOD and GSH-PX in CSF in acute purulent meningitis group was significantly Higher than the viral encephalitis group (P <0.05). Conclusion The determination of SOD and GSH-PX activity is helpful for the differential diagnosis of central nervous system infection and the judgment of the degree of brain damage.