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皮肤利什曼病是热带地区的一种地方性原虫病,每年全世界出现400000个新病例。巴西利什曼病的典型初发症状是皮肤溃疡,并多发生在下肢,数周或数年后累及粘膜。40多年来,葡萄糖酸锑钠一直用于治疗利什曼病,但其疗程长,副作用严重。粒细胞-巨噬细胞克隆刺激因子(GM-CSF)是骨髓干细胞的多能生长因子,可作用于Th1和Th2细胞。在体外,GM-CSF可以刺激巨噬细胞杀伤利什曼原虫,并可促进纤维化和组织损伤愈合。
Cutaneous leishmaniasis is a endemic protozoal disease in the tropics, with 400,000 new cases occurring each year worldwide. A typical initial symptom of Brazilian Leishmaniasis is skin ulceration, which occurs more frequently in the lower extremities, involving the mucosa after weeks or years. For more than 40 years, antimony gluconate has been used to treat leishmaniasis, but its long course and side effects. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent growth factor of bone marrow stem cells that acts on Th1 and Th2 cells. In vitro, GM-CSF stimulates macrophages to kill Leishmania and can promote fibrosis and tissue damage healing.