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表鬼臼毒甲醛糖甙(etoposide VP-16-213)是一种结构与VCR相关的半合成衍生物.试用于白血病和淋巴瘤始于1973年.其结构式为4-去甲基-9-〔4.6-0-亚乙基-D-吡喃葡萄糖苷〕.可在S期末或G_2期初阻遏细胞周期.抑制DNA合成的机理在于破坏DNA链.etoposide
Etoposide VP-16-213 is a semisynthetic derivative of VCR structure and has been used in leukemia and lymphoma since 1973. Its structure is 4-desmethyl-9- [4.6-0-Ethylidene-D-glucopyranoside] .Cell cycle can be arrested at the end of S phase or G 2 cycle.The mechanism of inhibiting DNA synthesis is to destroy the DNA chain.etoposide