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目的提高HSE(单纯疱疹病毒脑炎)的早期诊断和治愈率,减少病死率。方法对12例典型HSE患者临床特点,EEG、影像学、脑脊液(CSF)检查结果,治疗及预后进行回顾性分析。结果 HSE患者均呈急性或亚急性起病,主要临床表现为发热、头痛、意识及精神智能障碍,头颅MRI、EEG有利于早期诊断,脑脊液HSV特异性抗体可确诊。结论掌握HSE的临床特点,对HSE作出早期诊断及尽早使用抗病毒治疗是改善预后的关键。
Objective To improve the early diagnosis and cure rate of HSE (herpes simplex virus encephalitis) and reduce the case fatality rate. Methods The clinical features, EEG, imaging, cerebrospinal fluid (CSF) examination results, treatment and prognosis of 12 patients with typical HSE were retrospectively analyzed. Results The patients with HSE developed acute or subacute onset. The main clinical manifestations were fever, headache, consciousness and mental retardation. Head MRI and EEG were helpful for early diagnosis, and HSV specific antibody for cerebrospinal fluid could be diagnosed. Conclusions Mastering the clinical features of HSE, early diagnosis of HSE and early use of antiviral therapy are the keys to improve the prognosis.