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目的分析小剂量甲泼尼龙冲击疗法治疗小儿支原体肺炎的临床疗效及其对肿瘤坏死因子α(TNF-α)的影响。方法选取2012年4月—2016年4月宝鸡市妇幼保健院收治的支原体肺炎患儿96例,随机分为A组和B组,每组48例;另选取同期在本院体检健康儿童48例作为对照组。在常规对症治疗基础上,B组患儿给予阿奇霉素连续治疗3 d,A组患儿在B组治疗基础上给予甲泼尼龙连续治疗3 d。比较3组儿童血清TNF-α水平,A组与B组患儿临床疗效。结果 3组儿童血清TNF-α水平比较,差异有统计学意义(P<0.05);不同时间点比较,差异有统计学意义(P<0.05);方法和时间在血清TNF-α水平上存在交互作用(P<0.05)。A组患儿临床疗效优于B组(P<0.05)。结论小剂量甲泼尼龙冲击疗法治疗小儿支原体肺炎的临床疗效确切,可有效降低血清TNF-α水平。
Objective To analyze the clinical effect of low dose methylprednisolone impact therapy on children with mycoplasma pneumonia and its effect on tumor necrosis factor α (TNF-α). Methods From April 2012 to April 2016, 96 children with mycoplasma pneumonia admitted in Baoji Maternal and Child Health Hospital were randomly divided into group A and group B, 48 in each group. Another 48 healthy children As a control group. On the basis of routine symptomatic treatment, patients in group B were treated with azithromycin for 3 consecutive days. Patients in group A received continuous methylprednisolone treatment for 3 days on the basis of group B treatment. The level of serum TNF-α was compared between the three groups, and the clinical efficacy was evaluated in group A and group B. Results The serum levels of TNF-α in the three groups were significantly different (P <0.05), and the difference was statistically significant at different time points (P <0.05). There was interaction between serum TNF- (P <0.05). The clinical efficacy of group A was better than that of group B (P <0.05). Conclusion The small dose of methylprednisolone impact therapy for the treatment of Mycoplasma pneumonia in children is clinically effective and can effectively reduce the level of serum TNF-α.